Pharmaceutical product.



.ists,

LUDWIG- TAUB AND HANS HAHL, OF ELBERFELD, GERMANY, ASSIGNORS TO FARIBEN- FABRIKEN VORM. FRIEDR BAYER & 00., OF ELBERFELD, GERMANY, .A CORPORA- TIGN OF GERMANY.

Specification of Letters Patent.

Application filed September 1, 1911. Serial-No. 647,255.

n 1, .49 in @539 No Drawing.

PHARMACEUTICAL PRODUCT.

, Patented A r-.9, 1912.

T 0 all whom it may concern Be it known that'we, LUDWIG TAUB and HANS HAHL, doctors of philosophy, chemcitizens of the German Empire, residing at Elberfeld, Germany, have invented new and useful Improvements in New Pharmaceutical Products, of is a specification.

\Ve have found that new esters of glycol can be obtained by esterification of benzoic acid derivatives e. 9. nitro-, chloro-, or methylbenzoic acids with glycol. The new esters having most probably the following general formula:

which the following X meaning. a substituted phenyl, have the parts being by weight :-178.5 parts of.

the sodium salt of ortho-chloro-benzoic acid are heated with 80.5 parts of glycol chlorhydrin in an oil bath during i hours to 145 C. WVhen the solution is cooled ether is added to it and the ethereal solution is washed with soda and water. After drying the ether is distilled 0H and the residue is fractionated in cacao. The ester is a limpid oil which boils at 205 C. under a pressure of 20 mm. The ester obtained from the para-nitro-benzoic acid melts at 6390.

We claim v 1. The herein described glycol esters of benzoic acid derivatives of the formula:

X OOO.CH .CH OH Cl.C H,.COO.CH .CH .OH which is a limpid oil boiling at 205 C. un-

. der a pressure of 20 mm. and being a valuable remedy against scabies, substantially-as described.

In testimony whereof we have hereunto 'set our hands in the presence of two subscribing witnesses.

LUDWIG TAUB. 

